Police are calling for information following a serious single vehicle crash on the Midland Highway at Epping Forest last night.

Police and emergency services were tasked to a serious crash that had occurred in the southbound lane on the Midland Highway, near a U-turn bay, at Epping Forest, at about 8.10pm.

The 23-year-old man, who was the sole occupant of a blue Ford Falcon utility, was trapped in the vehicle until freed by members of the Tasmania Fire Service before being airlifted to the Royal Hobart Hospital in a serious but stable condition.

Northern Crash Investigation Services and Forensic Services attended the scene, with investigations into the cause of the crash ongoing. The Midland Highway was closed in both directions for approximately two hours while the Westpac Rescue Helicopter was at the scene.

Anyone who witnessed the crash or saw a blue Ford Falcon flat tray utility on the Midlands Highway prior to the crash should contact Longford Police on 131 444.