Police are investigating a serious crash involving a grey Toyota Corolla sedan and a grey Nissan Navara dual cab ute on the Bass Highway at Deloraine late last night.

Police and emergency services were called to the scene about 10:45 pm.

Preliminary investigations indicate the Navara, which was traveling west, and Corolla, which was travelling in the other direction, crashed head on after an attempt to overtake a truck about 1km west of the Deloraine eastern connector.

The sole occupant of the Corolla and the front passenger of the Navara were taken to the Launceston General Hospital with serious injuries.

The driver of the Navara and two other passengers were also taken to hospital.

The road was closed for four hours to allow crash investigators to examine the scene and conduct inquiries. Police would like to thank motorists for their patience and understanding.