Police are investigating a serious ATV crash on a farming property in Burnie about 10:30am today.

Initial investigations indicate the ATV was travelling down a hill when the rider lost control, causing him and his pillion passenger to be thrown from the vehicle.

The man was airlifted to the Royal Hobart Hospital with life-threatening injuries and remains in a serious condition.

His passenger was taken to the Northwest Regional Hospital with serious but non-life-threatening injuries.

Anyone with information about the crash who has not already spoken to investigators is asked to contact Burnie Police on 131 444.

Information can also be provided anonymously by calling Crime Stoppers on 1800 333 000 or online at crimestopperstas.com.au